* Gabriel Macht as Denny Colt / The Spirit: A rookie cop who returns from the dead to fight crime in Central City from the shadows. Miller had required actors who wanted the starring role to audition, and Macht was able to attain the role in August 2007. * Samuel L. Jackson as The Octopus: A villain who plans to wipe out all of Central City and will kill anyone unlucky enough to see his face. Jackson was Miller's first choice for the role and was cast in May 2007. * Scarlett Johansson as Silken Floss: A femme fatale secretary and accomplice to the Octopus. * Eva Mendes as Sand Saref. The actress told director Frank Miller that she wanted to work with him on The Spirit before she had seen a script for the film. * Sarah Paulson as Dr. Ellen Dolan: The police commissioner's daughter. * Dan Lauria as Commissioner Dolan. * Stana Katic as Morgenstern. * Johnny Simmons as Young Denny Colt. * Louis Lombardi as Phobos: One of the Octopus's henchmen. * Jaime King as Lorelei Rox. * Paz Vega as Plaster of Paris. * Meeghan Holaway as Holly.
